Small-molecule allosteric inhibitors of gpx4

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August undefined, 2024

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Small-molecule allosteric inhibitors of GPX4. NECAT

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WebbDiscovery and Characterization of a Novel Allosteric Small-Molecule Inhibitor of NADP +-Dependent Malic Enzyme 1（Biochemistry，2024/07/12） [NEW!] ※2024/07/20公開 … Encouraged by the dependence of drug-resistant, metastatic cancers on GPX4, we examined biophysical mechanisms of GPX4 inhibition, which revealed an … durham tech upswing

Small-molecule allosteric inhibitors of gpx4

Selective covalent targeting of GPX4 using masked nitrile-oxide ...

WebbIdentication of a small molecule as inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells Yahui Ding1, Xiaoping … Webb28 feb. 2024 · Encouraged by the dependence of drug-resistant, metastatic cancers on GPX4, we examined biophysical mechanisms of GPX4 inhibition, which revealed an …

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Webb15 dec. 2024 · Small-molecule allosteric inhibitors of GPX4 Hengrui Liu, Farhad Forouhar, Annie J. Lin, Qian Wang, Vasiliki Polychronidou, Rajesh Kumar Soni, Xin Xia, Brent R. … WebbGreat newly published article detailing GPX4 inhibition as a cancer treatment strategy. Highlights • The region around cysteine 66 (C66) is an allosteric… Dr. Jason R. Lewis …

Webb1 nov. 2024 · The identified a homozygous point mutation in the GPX4 gene, resulting in an R152H coding mutation, in three patients with Sedaghatian-type spondylometaphyseal … WebbLOC1886, CAS 951948-38-2, LOC-1886, GPX4 inhibitor, LOC1886 is a small molecule allosteric inhibitor of GPX4, inhibits enzymatic activity of GPX4 in HT1080 cell lysates …

Webb23 nov. 2024 · Small-molecule allosteric inhibitors of GPX4 - Newsroom News Details Liu et al. find that covalent binding of RSL3 to an allosteric site inhibits and degrades GPX4. … WebbSmall-molecule allosteric inhibitors of GPX4 Cell Press November 23, 2024 Encouraged by the dependence of drug-resistant, metastatic cancers on GPX4, we examined ...

WebbThe acquisition of m7G-cap-binding proteins is now recognized as a major variable driving the form and function of host RNAs. This manuscript compares the 5′-cap-RNA …

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