Cisplatin and hyponatremia

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August undefined, 2024

WebThe incidence of hyponatremia secondary to cisplatin can be as high as 43%, [ 6] the mechanism of action by which cisplatin induces hyponatremia is controversial. There … WebMar 24, 2024 · Carboplatin and oxaliplatin may have a lower incidence of hyponatremia relative to cisplatin containing regimens. 10 Of course, malignancy-specific risks of …

Cisplatin nephrotoxicity - UpToDate

WebHyponatremia is a common potential complication in cancer patients. It can be related to anticancer medical therapy. Vincristine, vinblastine, cisplatin and cyclophosphamide are the chemotherapeutic agents most frequently associated with hyponatremia. More recently, analogs such as carboplatin and ifosfamide have also been incriminated. WebAug 21, 2014 · The differential diagnosis between RSWS and SIADH for hyponatremic patients is sometimes difficult because of similarities in their clinical features, but careful consideration is needed to make... bit shifting operations

Hypokalemia, hypomagnesemia, and hyponatremia are …

WebA 66-year-old woman with small-cell lung cancer was administered chemo-radiotherapy consisting of cisplatin (CDDP) and etoposide (ETP). From day 3, she developed vomiting and hyponatremia that persisted despite fluid infusion and cortico-steroid administration. WebApr 12, 2024 · AKI-related cisplatin may also be associated with tubulopathies, such as Fanconi-like syndrome, hypomagnesemia, salt-loosing syndrome and distal renal tubular acidosis . Tubular dysfunction is characterized by electrolyte disorders such as hyponatremia, hypokalemia and hypomagnesemia. WebCisplatin-Induced Acute Kidney Injury and Renal Salt Wasting Syndrome. A treatment strategy that incorporates both water restrictions and sodium supplementation may be appropriate when differentiating between diagnoses of renal salt wasting syndrome and syndrome of inappropriate antidiuretic hormone secretion. data protection act 2018 or gdpr

Risk factors for severe hyponatremia related to cisplatin: a ...

WebJan 27, 2024 · Urothelial cancer of the bladder, renal pelvis, ureter, and other urinary organs is the fifth most common cancer in the United States, and systemic platinum-based chemotherapy remains the standard of care for first-line treatment of advanced/metastatic urothelial carcinoma (UC). Until recently, there were very limited options for patients who … WebNational Center for Biotechnology Information bit shifting vhdlWebJun 2, 2024 · Background: Cisplatin-associated acute kidney injury (C-AKI) is common. Predictive factors of C-AKI include age > 60 years, hypertension, cisplatin dose, … bit shifting right

"WebNov 10, 2024 · A phase I clinical trial of cisplatin and dose-escalating crolibulin was conducted in patients with advanced solid cancers, including recurrent or metastatic ATC. Of 16 patients with ATC, there was one patient with a complete response and one with stable disease. ... (33%), hyponatremia (29%), anemia (19%), hypertension during infusion … " - Cisplatin and hyponatremia

Cisplatin and hyponatremia

Syndrome of inappropriate secretion of anti-diuretic hormone …

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WebNov 12, 2024 · Very common (10% or more): Anorexia, hyponatremia Uncommon (0.1% to 1%): Hypomagnesemia Frequency not reported: Dehydration, hypokalemia, … WebMay 17, 2024 · If you have moderate, chronic hyponatremia due to your diet, diuretics or drinking too much water, your doctor may recommend temporarily cutting back on fluids. …

WebOnset of severe hyponatremia following cisplatin (CDDP) administration has been previously reported. However, the risk factors associated with hyponatremia still remain unclear. We conducted a retrospective, single-center, case-control study to identify independent risk factors of severe hyponatremia in patients with various types of cancers. WebDec 16, 2024 · Cisplatin (CDDP; cis-dichlorodiammine platinum [II]) is a non-specific drug of the cell cycle with strong cytotoxicity and broad-spectrum antitumor effects; it is widely used in urogenital system tumors, malignant lymphoma, breast cancer, head and neck cancer, non-small cell lung cancer, etc. ( 1 – 3) Cisplatin-induced nephrotoxicity is …

WebJun 2, 2024 · Background: Cisplatin-associated acute kidney injury (C-AKI) is common. Predictive factors of C-AKI include age > 60 years, hypertension, cisplatin dose, diabetes, and serum albumin < 3.5g/L. The association between C-AKI and hypokalemia, hypomagnesemia or hyponatremia has not been well characterized to date. WebHyponatremia of grade 3 or above developed in 30.7% of the generic CDDP group compared to 15.1% of the brand-name CDDP group ( P =0.011). Multivariate analysis showed that the use of generic CDDP increased the incidence of hyponatremia (odds ratio =5.661, 95% confidence interval =1.403–22.839; P =0.015). Conclusion: Oncologists …

Webcisplatin, docetaxel and 5-fluorouracil-containing chemotherapy who suffered from acute-onset consciousness disturbance due to hyponatremia just after administration of …

WebMay 19, 2024 · Cisplatin treatment may cause hyponatremia through SIADH, related to both higher secretion of and sensitivity to ADH ( 32 ). Nausea and vomiting, which are … bit shifting to the rightWebApr 6, 2024 · Treatment-related grade 3/4 hyponatremia was reported in 5%–7% of MIBC patients treated with pre-operative ... NAC and prolonged survival. 34-36 It is hypothesized that these mutations may increase the sensitivity of tumor cells to cisplatin-induced DNA damage, thereby enhancing the drug's efficacy in these tumors. 37 The incidence of DDR ... data protection act 2018 medical recordsWebJun 11, 2024 · INTRODUCTION Hyponatremia represents a relative excess of water in relation to sodium. It can be induced by a marked increase in water intake (primary polydipsia) and/or by impaired water excretion due, for example, to advanced kidney failure or persistent release of antidiuretic hormone (ADH). (See "Causes of hypotonic … bitshift in matlabWebJan 13, 2024 · In addition, significant hyponatremia signals were detected for oesophageal, lung, and renal cancers. Conclusions: Hyponatremia has been reported in women and patients with lung cancer... bit shift in matlabWebmostly solid tumors had hyponatremia, and of these, 11% had moderate (sodium [Na] 120–129 mEq/L) to severe (Na , 120 mEq/L) hyponatremia (1). This is disproportionately higher than the hyponatremia prevalence rates of 15%–30% reported for general medicine admissions (2). In cancer patients with nonsolid tumors, rates of hyponatremia are less. bit shift left c++WebFeb 1, 1995 · Cisplatin, pharmacology and clinical applications Article Feb 2012 S. Ithimakin View Show abstract A Case of Severe Hyponatremia Caused by Renal Salt Wasting Syndrome in Oropharyngeal Cancer... bit shift in pythonWebNov 21, 2024 · Cisplatin probably causes hyponatremia by causing SIADH and through its effect on the kidneys. ( 5 Trusted Source A Review of Drug-induced Hyponatremia Go to source) Painkillers: Opiates,... data protection act 2018 penalties for breach