WebDec 6, 2024 · Interestingly, the translation initiation of CHSY1 was suppressed by a highly structured sequence (positions -202 to -117 relative to the initiation codon) containing RNA G-quadruplex (G4) structures in 5'-untranslated region. WebDec 10, 2010 · CHSY1 encodes a type II transmembrane protein comprising a Fringe motif and a glycosyltransferase domain. CHSY1 was found to be secreted, and functional …
Cell line - CHSY1 - The Human Protein Atlas
WebJul 9, 2024 · Protease activated receptors (PARs) transactivate both epidermal growth factor receptors (EGFR) and transforming growth factor (TGF)-β receptors (TGFBR1) in vascular smooth muscle leading to the increased expression of genes (CHST11 and CHSY1) which are rate limiting for the enzymes that mediate hyperelongation of … WebNov 11, 2024 · TGF-β1 acting through its receptor leads to the phosphorylation of the transcription factor Smad2 linker region, a response associated with TGF-β1-mediated mRNA expression of GAG … littlebits arduino project
Loss of CHSY1, a secreted FRINGE enzyme, causes syndromic brachydactyly ...
WebJan 1, 2014 · Temtamy preaxial brachydactyly syndrome (TPBS) is an autosomal recessive rare disorder characterized by hyperphalangism of digits, facial dysmorphism, dental anomalies, sensorineural hearing loss, delayed motor and mental development, and growth retardation. Loss of function mutations have been recently reported in the CHSY1 gene … WebDec 13, 2024 · Oncofetal chondroitin sulfate expression plays an important role in the development of tumors and the pathogenesis of malaria in pregnancy. However, the biosynthesis and functions of these chondroitin sulfates, particularly the tissue-specific regulation either in tumors or placenta, have not been fully elucidated. Here, by … Chondroitin sulfate synthase 1 is an enzyme that in humans is encoded by the CHSY1 gene. CHSY1 synthesizes chondroitin sulfate, a glycosaminoglycan expressed on the surface of most cells and in extracellular matrices. Glycosaminoglycan chains are covalently linked to a wide range of core protein families and regulate many bio… little bits at home starter kit