Calsyntenin 3β
WebMay 22, 2024 · Publisher Correction: Innervation of thermogenic adipose tissue via a calsyntenin 3β–S100b axis. Xing Zeng 1,2, Mengchen Ye 3, Jon M. Resch 4, Mark P. Jedrychowski 1,2, Bo Hu 1,2, Bradford B ... WebMar 4, 2024 · Recently, the study by Zeng et al. showed the role of calsyntenin 3β (CLSTN3β), a mammal-specific membrane protein, to promote sympathetic innervation in brown and beige adipocytes. Through loss and gain of function experiments, the authors demonstrated that CLSTN3β is localized in the endoplasmic reticulum and induces the …
Calsyntenin 3β
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WebMar 6, 2024 · Previous studies have shown that adipose-specific calsyntenin 3β induces the expression of secreted factor S100β to promote sympathetic innervation of BAT and beige adipocytes 8. WebMoreover, Zeng et al. show that a previously unknown protein, named calsyntenin 3β (CLSTN3β), promotes the sympathetic innervation of both brown and beige adipocytes [91]. CLSTN3β binds to and ...
WebApr 28, 2024 · A recent study has identified calsyntenin 3β (CLSTN3β), a mammal-specific protein of the endoplasmic reticulum, as a key regulator of S100B secretion in brown adipocytes . It has been proposed that CLSTN3β may function as a chaperone for targeting S100B to the ER for subsequent secretion via the trans-Golgi network . A stricto sensus ... WebMechanistically, calsyntenin 3β promotes endoplasmic-reticulum localization and secretion of S100b-a protein that lacks a signal peptide-from brown adipocytes. S100b stimulates …
WebMar 16, 2024 · The newly identified calsyntenin 3β protein has a role in the innervation of thermogenic fat through a mechanism of communication—which is unique to mammals—between thermogenic adipocytes and ... Webcalsyntenin 3β interacts physically with S100b, and thereby acts as a chaperone protein that directs and aids the secretion of newly formed S100b from the ER. The authors …
WebJan 29, 2024 · Calsyntenin-3 interacts with both α- and β-neurexins in the regulation of excitatory synaptic innervation in specific Schaffer collateral pathways. Kim H, et al. J Biol Chem, 2024 Jul 3. PMID 32434929, Free PMC Article. CLSTN3 gene variant associates with obesity risk and contributes to dysfunction in white adipose tissue.
WebCalsyntenin 3β Is Dynamically Regulated by Temperature in Murine Brown Adipose and Marks Human Multilocular Fat Frontiers in Endocrinology September 25, 2024 ... south pine counselingWebMar 31, 2016 · View Full Report Card. Fawn Creek Township is located in Kansas with a population of 1,618. Fawn Creek Township is in Montgomery County. Living in Fawn … tea cup merry go roundWebJul 3, 2024 · Calsyntenin-3 (Clstn3) is a postsynaptic adhesion molecule that induces presynaptic differentiation via presynaptic neurexins (Nrxns), but whether Nrxns directly … tea cup microwave dessertsWebCalsyntenin 3beta (UniProt: A0A4P8DYG6; also known as Calsyntenin-3β, CLSTN3β) is encoded by the Clstn3 (also known as Clstn3b) gene (Gene ID: 232270) in murine … southpine bakeryWebABS2236-25UG. Description. Anti-CLSTN3b. Background Information. Calsyntenin 3beta (UniProt: A0A4P8DYG6; also known as Calsyntenin-3β, CLSTN3β) is encoded by the Clstn3 (also known as Clstn3b) gene (Gene ID: 232270) in murine species. CLSTN3β is a mammal-specific that is preferentially expressed in thermogenic adipocytes and is … teacup maltese weight chartWebJul 14, 2024 · Calsyntenin 3β, a novel endoplasmic reticulum (ER)-localized protein unique to mammals, is responsible for orchestrating the export of S100b. The clustering effect of thermogenic adipocytes can partly be explained as an effort to propagate the output of SNS afferents in adipose tissue. These findings affirm the fundamental importance of SNS ... south pine investment groupWebApr 14, 2024 · Recently Concluded Data & Programmatic Insider Summit March 22 - 25, 2024, Scottsdale Digital OOH Insider Summit February 19 - 22, 2024, La Jolla teacup maltichon puppies for sale